Paul Hockings (Senior Director MR Imaging at Antaros Medical and Adjunct Professor at Chalmers University of Technology) will be presenting research evaluating a novel method for assessing hemodynamics next week at the 61st European Renal Association (ERA) Annual Congress.
This research is a continuation of a long-standing collaboration that was established between Antaros Medical, Sahlgrenska University Hospital and AstraZeneca looking at non-invasive MRI biomarkers for use throughout drug development in diabetic kidney disease (DKD).
Renal hemodynamic dysfunction, specifically glomerular dysfunction, is a key feature of DKD and its progression. Filtration fraction (FF), an important measure of glomerular hemodynamics, is the ration of the glomerular filtration rate (GFR) to the renal plasma flow (RPF). However, the current gold standard for assessing RPF is via renal clearance of para-aminohippuric acid (PAH), the technical demands of which limits its utilisation in DKD clinical trials. A quicker and simpler method for measuring FF is needed to enable assessment of renal hemodynamic dysfunction and effects of therapeutic interventions.
A novel magnetic resonance imaging (MRI) technique for measuring FF was evaluated in individuals with DKD and healthy controls. A phase-contrast MRI of the renal artery of each kidney enabled quick and simple measurement of FF. This MRI method can therefore facilitate the inclusion of FF in clinical trials and can also provide insights into glomerular dysfunction such as hyper- or hypofiltration, which can influence results in DKD clinical trials.
Abstract title: Novel MRI Filtration Fraction Method to Assess Glomerular Hemodynamics in Diabetic Kidney Disease
Authors: Hockings P, Makvandi K, Unwin R, Hulthe J, Baid-Agrawal S
Focused Oral in Chronic Kidney Disease session, May 24 at 8:30 – 9:45 CEST
The European Renal Association (ERA) Congress is the largest nephrology congress in Europe. This year it will take place from May 23-26 in Stockholm, Sweden as well as virtually. Find the entire Scientific Programme here.