There was a great interest at the annual European Association for the Study of Diabetes (EASD) 2018 in Berlin for the results generated by Antaros Medical. The two studies were done in collaboration with AstraZeneca and MedImmune, respectively.
Precision is key when choosing methods for decision making in drug development to ensure accurate understanding of efficacy. Metabolic dysfunction-associated steatotic liver disease (MASLD; previously called non-alcoholic fatty liver disease or NAFLD) and metabolic dysfunction-associated steatohepatitis (MASH; previously called non-alcoholic steatohepatitis or NASH) studies using MRI-PDFF covers the entire liver in a single breath-hold and enables quantification of changes in total liver fat.
Figure 1. Lars Johansson, CSO, at EASD 2018
Lars Johansson, CSO, Antaros Medical comments: “The Antaros methodology measures both the liver volume and liver fat from the entire liver. This is of importance to improve the accuracy of liver fat measurements and allows for further understanding of drug specific mode of action.”
Figure 2. PDFF and Liver Volume
ePoster # 647
Authors: Lars Johansson, Paul Hockings, Eva K Johnsson, Jill Maaske, Ricardo Garcia-Sanchez, John P Wilding
Abstract # 727
Authors: Philip Ambery, Lan-Feng Tsai, Darren Robertson, Boaz Hirshberg, Paul Hockings, Lars Johansson Meena Jain.