Iina Laitinen (Senior Director PET Imaging at Antaros Medical) is presenting new data on repeatability of PET-MRI assessment of tissue specific insulin resistance in type 2 diabetics at EASD 2022. The abstract “Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp. A repeatability study in T2DM subjects” will be presented as a short oral discussion on Wednesday the 21st of September. The study has been performed as a collaboration between Antaros Medical, Eli Lilly and Company and Avid Radiopharmaceuticals, together with Clinical Trial Consultants in Uppsala, Sweden.
Type 2 diabetes (T2D) is a global health problem affecting over 400 million people worldwide and the disease prevalence is only expected to increase. T2D is associated with downstream complications e.g. affecting the liver, kidney and heart, and there is a need for more holistic treatment options. Multi-organ approaches to investigate the disease and potential new treatments are needed.
Loss of insulin sensitivity and altered glucose metabolism are important components in the development of T2D. The M-value determination under hyperinsulinemic euglycemic clamp (HEC) is the current reference standard for measuring insulin sensitivity, limited as a multi-organ approach by being a systemic measure. Imaging with 18F-FDG-PET combined with MRI under HEC is a method for assessing insulin sensitivity, allowing for tissue-specific read-out as well as whole body glucose uptake. The abstract at EASD 2022 presents new data on the repeatability of a whole-body dynamic PET/MRI imaging method in T2D patients, demonstrating potential to provide benefits in monitoring and evaluating T2D treatment effects in interventional trials with a multi-organ approach.
Find the abstract here
Abstract title: Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp. A repeatability study in T2DM subjects.
Abstract number: 462
Authors: Laitinen I, Litorp H, Sjöberg F, Haraldsson H, Ekström S, Pierrou S, Southekal S, Lu M, Coskun T, Milicevic Z, Johansson L