New improved method for radiometabolite analysis of fatty acid uptake

Metabolic diseases such as type 2 diabetes (T2D) and obesity are associated with changes in fatty acid metabolism. Fatty acid uptake (FAU) in various tissues can be assessed using positron emission tomography (PET) imaging with the [18F]FTHA radiotracer.

Quantitative assessment of FAU using [18F]FTHA PET imaging requires kinetic modelling using both imaging data and plasma radiotracer levels. As part of a method development study designed to look at FAU in various tissues in both fasted and postprandial conditions, a new improved radiometabolite analysis method was developed to enable accurate data analysis from a [18F]FTHA PET imaging study.

The method development study was performed as a collaboration between Turku PET Centre, Eli Lilly and Company, Clinical Research Services Turku – CRST Oy, and Antaros Medical. Results from this study have previously been presented at the American Diabetes Association (ADA) Scientific Sessions and the European Association for the Study of Diabetes (EASD) Congress.

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Title: New improved radiometabolite analysis method for [18F]FTHA from human plasma: a test-retest study with postprandial and fasting state
Authors: Aarnio R, Kirjavainen A, Rajander J, Forsback S, Kalliokoski K, Nuutila P, Milicevic Z, Coskun T, Haupt A, Laitinen I, Haaparanta-Solin M

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