The DAPA-12 study showed reduced adipose tissue in patients with Type 2 Diabetes mellitus following dapagliflozin treatment. This was a multicenter, multivendor study in three European countries.
Bolinder J, Ljunggren Ö, Kullberg J, Johansson L, Wilding J, Langkilde AM, Sugg J, Parikh S.
Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin.
J Clin Endocrinol Metab. 2012 Mar;97(3):1020-31